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教授
吴祥
发布时间:2024-01-31    阅读次数:11869

姓 名:
吴祥
职 称:
教授,博士生导师
职 务:
应用化学系主任
所属系:
应用化学系
邮 箱:
wuxiang@hfut.edu.cn
电   话:
   
                                                                 

个人简历

2001.09-2005.06,南开大学化学学院,学士

2005.09-2010.12,南开大学元素有机化学国家重点实验室,博士

2010.12-2012.08,苏州诺华制药科技有限公司,高级研究员

2012.08-2014.12,中国科学技术大学微尺度物质科学国家实验室,博士后

2014.12-2015.08,美国宾夕法尼亚州立大学化学系,博士后

2015.08-2021.11,合肥工业大学化学与化工学院应用化学系,副教授

2021.12-至今,合肥工业大学化学与化工学院应用化学系,教授

主要研究领域、方向

课题组主页—http://121.251.19.227/_s181/main.psp

硕士生招生专业:化学(学术型);化学工程(专业型)

目前的研究方向:不对称催化和有机反应方法学;精细化工产品合成

主讲本科生课程:《有机合成》、《精细有机合成工艺学》、《现代仪器分析》

主讲研究生课程:《波谱分析及现代测试技术》

研究成果(代表性成果) 

(1)氧化不对称环加成反应;

(2)精细化学品的合成及其产业化。

目前承担科研项目   

主持承担及完成的主要项目:

1. 2021年安徽省重点研究与开发计划,主持人,在研;

2. 烟草化学安徽省重点实验室2021年度开放课题,主持人,在研;

3. 合肥工业大学2020年度“科学前沿创新专项”一般项目,主持人,结题;

4. 先进催化材料与反应工程安徽省重点实验室2019年“自主创新专项”重点项目,主持人,结题;

5. 合肥工业大学2018年质量工程青年教师教学研究项目,主持人,结题;

6. 合肥工业大学2018创新创业精品课程建设计划,主持人,结题;

7. 国家自然科学基金面上基金(批准号:21672049),2017.01-2020.12,主持人,结题;

8. 合肥工业大学2016年度校级课程规划设计研究项目,主持人,结题;

9. 国家自然科学基金青年基金(批准号:21302177),2014.01-2016.12,主持人,结题;

10. 合肥工业大学引进人才启动资金(2015年),主持人,在研;

11. 国家级大学生创新创业训练计划项目(2016年),指导教师;

12. 中国博士后科学基金面上基金(批准号:2014M551807),2014.05-2014.12,主持人,结题。

获奖及专利情况

获奖:

第八届安徽省(2022年)“互联网+”大学生创新创业大赛创意组金奖指导教师

合肥工业大学2020年优秀共产党员

合肥工业大学2020届本科毕业设计(论文)优秀指导教师

合肥工业大学2018年度优秀班主任

合肥工业大学2018届本科毕业设计(论文)优秀指导教师

合肥工业大学2016年青年教师教学基本功比赛三等奖

第二届安徽省(2016年) “互联网+”大学生创新创业大赛初创组银奖指导教师

安徽省高校教师“师德师风”演讲比赛三等奖

安徽省委教育工委“好校风、好家风、好故事”演讲邀请赛二等奖

专利:

1. 吴祥,汪亚婷,王文斌,陈超,库进良,江龙,朱成峰,张文成。一种提高黑果枸杞中原花青素稳定性的方法。中国发明专利,申请公布号:CN115844013A。

2. 吴祥,张一新,汪亚婷,赵利萍,付延明,朱成峰,李有桂。一种提高黑果枸杞玫瑰果膏中原花青素稳定性的方法。中国发明专利,申请公布号:CN114634475A。

3. 吴祥,赵利萍,谢金明,付延明,朱成峰,李有桂。一种多取代3-磺酰胺喹啉化合物的合成方法。中国发明专利,专利号:ZL 2021 1 1008249.3

4. 吴祥,黄永双,宋双桂,周旸焜,赵丽娜,鲍友美。一含有酸基的金鸡纳碱伯胺催化剂及其合成方法和在不对称反应中的应用。中国发明专利,专利号:ZL 2018 1 1317969.6。

5. 吴祥,张登华,黄智勇,姚远,李文轩,王熙程,朱成峰,李有桂。一种手性苯并[a]喹嗪-2-酮类化合物及其不对称催化合成方法。中国发明专利,专利号:ZL 2017 1 0328501.6。

6. 吴祥,赵仕宝,黄永双,朱海杰,李有桂。手性四氢咔唑衍生物的不对称合成。中国发明专利。中国发明专利,专利号:ZL 2017 1 0864304.6。

著作论文(代表作)

(1) Yun-Long Zhu, Yi-Fan Dong, Si-Ru Wang, You-Gui Li,* Xiang Wu,* and Long-Wu Ye, Nucleophile-Controlled Trapping of Gold Carbene by Nitriles and Water: Synthesis of 5H-Pyrimido[5,4-b]Indoles and 2-Benzylidene-3-Indolinones. Organic Letters, 2024, 26, 631-635.

(2) Tao Wang, Wen-Bin Wang, Yan-Ming Fu, Cheng-Feng Zhu, Lan-Jun Cheng, Yang-En You, Xiang Wu,* and You-Gui Li*, Asymmetric Double Oxidative [3 + 2] Cycloaddition for the Synthesis of CF3-Containing Spiro[Pyrrolidin-3,2'-Oxindole], Organic Letters, 2023, 25, 3152-3156.

(3) You-Gui Li, Wei-Ke Chen, You-Qiang Guo, Zhang Zhu, Jing-Jing Cao, Zhen-Yu Wang, Xiang Wu,* Synthesis of Hexahydropyrrolo-Isoquinolines by 1,3-Dipolar Cycloaddition of Tetrahydroisoquinolines and Cinnamaldehydes, Tetrahedron Letters, 2023, 122, 154519.

(4) Jin-Ming Xie, Yun-Long Zhu, Yan-Ming Fu, Cheng-Feng Zhu, Lan-Jun Cheng, Yang-En You,* Xiang Wu*, You-Gui Li, Gold-Catalyzed Cascade Reaction of 2-Alkynyl Aryl Azides with Enecarbamates for Direct Synthesis of α-(3-Indolyl)ketones, Organic Letters, 2023, 25, 421-425.

(5) Xiang Wu*, Access to Chiral 1-Aminoindene Derivatives by Asymmetric Br?nsted Acid Catalysis, Synlett, 2022, 33, 513-517.

(6) Xiang Wu*, Li-Ping Zhao, Jin-Ming Xie, Yan-Ming Fu, Cheng-Feng Zhu, You-Gui Li*, Access to 3-Sulfonamidoquinolines by Gold-Catalyzed Cyclization of 1-(2'-Azidoaryl)Propargylsulfonamides through 1,2-N Migration, The Journal of Organic Chemistry, 2022, 87, 801-812.

(7) Jianfeng Zheng, Xiang Wu*, Wei-Dong Z. Li*, A Model Study for the Total Synthesis of Lophotoxin, Tetrahedron Letters, 2021, 85, 153481.

(8) Xiang Wu*, Du Ding,§ Ying Zhang,§ Hua-Jie Jiang, Tao Wang, Li-Ping Zhao, Enantioselective Synthesis of 1-Aminoindene Derivatives Via Asymmetric Br?nsted Acid Catalysis, Chemical Communications, 2021, 57, 9680-9683.

(9) Xiang Wu*, Shuang-Gui Song, Xin Zhang, Yan-Ming Fu, Cheng-Feng Zhu, You-Gui Li*, Copper‐Catalyzed Direct Oxidative α‐Alkoxylation of 4‐Isochromanones, European Journal of Organic Chemistry, 2021, 2021, 2436-2439.

(10) Xiang Wu*, Zheng-Hao Zhu, Hao He, Lei Ren, Cheng-Feng Zhu, You-Gui Li*, Construction of 1,3-Oxazolidines through a Three-Component [3+2] Cycloaddition of Tetrahydroisoquinolines, Aldehydes, and Ethyl Ketomalonate, The Journal of Organic Chemistry, 2020, 85, 6216?6224.

(11) Xiang Wu*, Lang-Lang Zheng, Li-Ping Zhao, Cheng-Feng Zhu, You-Gui Li*, Gold-Catalyzed Cyclization of 1-(2'-Azidoaryl) Propynols: Synthesis of Polysubstituted 4-Quinolones, Chemical Communications, 2019, 55, 14769-14772.

(12) Yong-Shuang Huang, Shuang-Gui Song, Lei Ren, You-Gui Li, Xiang Wu*, Enantioselective γ-Alkylation of α,β-Unsaturated Aldehydes Using New Cinchona-Based Primary Amine Catalyst, European Journal of Organic Chemistry, 2019, 6838-6841.

(13) Ying Zhang§, Hong-Cheng Shen§, Yang-Yang Li, Yong-Shuang Huang, Zhi-Yong Han, Xiang Wu*, Access to Chiral Tetrahydrofluorenes through a Palladium-Catalyzed Enantioselective Tandem Intramolecular Heck/Tsuji-Trost Reaction, Chemical Communications, 2019, 55, 3769-3772. (§ Equal contribution).

(14) Xiang Wu, Liu-Zhu Gong*, Palladium(0)-Catalyzed Difunctionalization of 1,3-Dienes: From Racemic to Enantioselective, Synthesis, 2019, 51, 122-134.

(15) Hai-Jun Wang, Lei Guo, Cheng-Feng Zhu, Yun-Fei Luo, You-Gui Li, Xiang Wu *, Pd/C-Catalyzed Dehydrogenative [3+2] Cycloaddition for the Synthesis of Functionalized Tropane, European Journal of Organic Chemistry, 2018, 2018, 5456-5459.

(16) Xiang Wu*, Shi-Bao Zhao, Lang-Lang Zheng, You-Gui Li*, Oxidative Asymmetric Formal Aza-Diels-Alder Reactions of Tetrahydro-β-Carboline with Enones in the Synthesis of Indoloquinolizidine-2-Ones, Molecules, 2018, 23, 2228.

(17) Xiang Wu§, Shu-Sen Chen§, Ling Zhang, Hai-Jun Wang, Liu-Zhu Gong*, Palladium-Catalyzed Enantioselective Carboannulation of 1,3-Dienes with Aryl Iodides Enables Access to Chiral Indanes, Chemical Communications, 2018, 54, 9595-9598. (§ Equal contribution).

(18) Xiang Wu*, Hai-Jun Wang, Yong-Shuang Huang, Wei-Dong Z. Li*, Intramolecular [2 + 2] Cycloadditions of Alkyl(Phenylthio)Ketenes: Total Synthesis of (+)-Sphaerodiol, Organic Letters, 2018, 20, 1871-1874.

(19) Xiang Wu*, Hai-Jie Zhu, Shi-Bao Zhao, Shu-Sen Chen, Yun-Fei Luo, You-Gui Li, An Asymmetric Dehydrogenative Diels-Alder Reaction for the Synthesis of Chiral Tetrahydrocarbazole Derivatives, Organic Letters, 2018, 20, 32-35.

(20) Yuan Yao, Hai-Jie Zhu, Fang Li, Cheng-Feng Zhu, Yun-Fei Luo, Xiang Wu*, Eric Assen B. Kantchev*, Ruthenium-Catalyzed Oxidative Formal Aza-Diels-Alder Reaction: Enantioselective Synthesis of Benzo[a]Quinolizine-2-Ones, Advanced Synthesis & Catalysis, 2017, 359, 3095-3101.

(21) Xiang Wu*, Wei-dong Z. Li*, Unexpected Grob-Type Fragmentation of Vinylogous Beta-Silyloxy-Cyclobutanone into γ-Lactone, Chinese Chemical Letters, 2017, 28, 968-970.

(22) Xiang Wu§, Hua-Chen Lin§, Ming-Li Li, Lu-Lu Li, Zhi-Yong Han, Liu-Zhu Gong*, Enantioselective 1,2-Difunctionalization of Dienes Enabled by Chiral Palladium Complex-Catalyzed Cascade Arylation/Allylic Alkylation Reaction, Journal of the American Chemical Society, 2015, 137, 13476-13479. (§ Equal contribution).

(23) Ming-Li Li, Dian-Feng Chen, Shi-Wei Luo, Xiang Wu*, Chiral Br?nsted Acid Catalyzed Intermolecular Friedel-Crafts Alkylation of Styrenes with Indoles: Construction of All-Carbon Quaternary Stereocenters, Tetrahedron: Asymmetry, 2015, 26, 219-224. 

(24) Xiang Wu*, Dian-Feng Chen, Shu-Sen Chen, Yi-Fan Zhu, Synthesis of Polycyclic Amines through Mild Metal-Free Tandem Cross-Dehydrogenative Coupling/Intramolecular Hydroarylation of N-Aryltetrahydroisoquinolines and Crotonaldehyde, European Journal of Organic Chemistry, 2015, 468-473.

(25) Xiang Wu, Shu-Sen Chen, Yue Hu, Liu-Zhu Gong*, Gold-Catalyzed [1,5]-Hydride Shift onto Unactivated Alkynes to Trigger an Intermolecular Diels-Alder Reaction, Organic Letters, 2014, 16, 3820-3823.

(26) Xiang Wu*, Ming-Li Li, Pu-Sheng Wang, Enantioselective Construction of [6,5,6]-Carbocyclic Systems by Organo/Metal-Catalyzed Sequential Reactions, The Journal of Organic Chemistry, 2014, 79, 419-425. 

(27) Xiang Wu*, Ming-Li Li, Dian-Feng Chen, Hybrid Gold/Chiral Br?nsted Acid Relay Catalysis Allows an Enantioselective Synthesis of (-)-5-epi-Eupomatilone-6, The Journal of Organic Chemistry, 2014, 79, 4743-4750.

(28) Xiang Wu, Ming-Li Li, Liu-Zhu Gong*, Asymmetric Relay Catalysis Reaction Consisting of Metal Complex and Chiral Phosphoric Acids, Acta Chimica Sinica, 2013, 71, 1091-1100. 

(29) 吴祥,朱成峰,付延明,李芳,李冰,李有桂,新工科背景下应用化学专业工程创新能力培养体系的建设,大学化学,2021, 36(11), 2107094。

(30) 吴祥,李有桂,朱成峰,李芳,李冰,基于对分课堂的精细有机合成工艺学课程教学模式探索,化工高等教育,2020,37(4),64-69。

专著:

1. Xiang, Wu; Liu-Zhu, Gong. Multicomponent Reactions in Organic Synthesis,Chapter 15:Chiral Phosphoric Acid-Catalyzed Asymmetric Multicomponent Reactions. Weinheim, Germany: Wiley-VCH, 2015.

教材:

1. 参编《有机合成化学》,化学工业出版社,2016年1月。

2. 主编《有机合成化学习题集》,合肥工业大学出版社,2021年4月。

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